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Month in Review-January & February 2018


  • Losina E, Usiskin IM, Smith SR, Sullivan JK, Smith KC, Hunter DJ, Messier SP, Paltiel AD, Katz JN. Cost-effectiveness of generic celecoxib in knee osteoarthritis for average-risk patients: A model-based evaluation. Osteoarthritis Cartilage. 2018 Feb 23. PMID: 29481917.
  • Collins JE. What can our hands tell us about the future of our knees? Arthritis Rheumatol. 2018 Feb 22. PMID: 29471592.
  • Losina E, Katz JN. Hydroxychloroquine: another battle lost in the campaign to find effective therapies for hand osteoarthritis. Ann Intern Med. 2018 Feb 20. PMID: 29459984.
  • Rajan PV, Qudsi RA, Dyer GSM, Losina E. The cost-effectiveness of surgical fixation of distal radial fractures: a computer model-based evaluation of three operative modalities. J Bone Joint Surg Am. 2018 Feb 7;100(3):e13. PMID: 29406347.
  • Sorensen G, Sparer E, Williams JAR, Gundersen D, Boden LI, Dennerlein JT, Hashimoto D, Katz JN, McLellan DL, Okechukwu CA, Pronk NP, Revette A, Wagner GR. Measuring best practices for workplace safety, health and wellbeing: the Workplace Integrated Safety and Health Assessment. J Occup Environ Med. 2018 Jan 31. PMID: 29389812.
  • Meier M, Webb J, Collins JE, Beckmann J, Fitz W. Do modern total knee replacements improve tibial coverage? Knee Surg Sports Traumatol Arthrosc. 2018 Jan 25. PMID: 29372284.
  • Smith KC, Michl GL, Katz JN, Losina E. Meteorologic and geographic barriers to physical activity in a workplace wellness program.J Phys Act Health. 2018 Feb 1;15(2):108-116. PMID: 28872399.
  • KermanHM, Smith SR, Smith KC, Collins JE, Suter LG, Katz JN, Losina E. Disparities in total knee replacement: Population losses in quality-adjusted life years due to differential offer, acceptance, and complication rates for Black Americans. Arthritis Care Res (Hoboken). 2018 Jan 24. PMID: 29363280
  • Solomon DH, Lu B, Yu Z, Corrigan C, Harrold LR, Smolen JS, Fraenkel L, Katz JN, Losina E. Benefits and sustainability of a learning collaborative for implementation of treat to target in rheumatoid arthritis: results of the TRACTION Trial Phase II. Arthritis Care Res (Hoboken). 2018 Jan 5. PMID: 29316341.


News Coverage

Coverage of Kerman et al., “Disparities in total knee replacement: Population losses in quality-adjusted life years due to differential offer, acceptance, and complication rates for Black Americans”:

AAAS EurekAlert

Healio Rheumatology

Reuters Health News Features OAPol Analysis

An OAPol analysis published last month in Arthritis Care & Research examined the loss of quality-adjusted life years among racial minorities due to disparities in total knee replacement utilization. Click here for coverage by Reuters Health.

Dr. Losina Named Robert W. Lovett Professor of Orthopaedic Surgery

Dr. Elena Losina was appointed this year as the Robert W. Lovett Professor of Orthopedic Surgery at Harvard Medical School (HMS). Endowed professorships, the highest honor granted to faculty by HMS, recognize researchers, physicians, and professors making outstanding contributions to their fields.

Robert W. Lovett was a pioneering orthopedist known in particular for his study of polio. Born in 1859, Lovett attended Harvard and subsequently joined the faculty at HMS. In his work on rehabilitation in polio patients, he advanced the use of objective measures of muscle strength. Lovett also authored (with Robert Jones) an early complete textbook of orthopedic surgery. In recognition of this legacy, the Robert W. Lovett fund was established in 1926 to support the study of musculoskeletal disorders and was subsequently converted into an endowed professorship.

A reception honoring Dr. Losina was held in November at Brigham and Women’s Hospital. The event highlighted Dr. Losina’s work in musculoskeletal research.

The appointment is described on the HMS Endowed Professors page.





Source: Peltier, Leonard F. “Orthopedics: A History and Iconography.” San Francisco: Norman Publishing. 1993.

PIVOT Center Research on Opioid Use Featured

Brigham Vital Lines offers news for physicians about research and clinical practice at Brigham and Women’s Hospital. Vital Lines recently featured research by Dr. Losina and colleagues at the PIVOT Center. The team found that preoperative opioid use was associated with poor pain outcomes 6 months after total knee replacement (TKR) among 156 TKR recipients. The study was published this spring in the Journal of Bone and Joint Surgery.

Click here to read the story and learn more about opioid use in knee osteoarthritis.

OA Risk Calculator

This month, OrACORe and PIVOT released an updated model of the Osteoarthritis Risk Calculator (OA Risk C). This interactive, web-based education tool calculates a user’s risk of OA and of undergoing TKR, based on demographic and risk factor information. For more about how we developed this tool, click here.

Risk calculators exist for many prevalent conditions with modifiable risk factors, such as heart disease, cancer, and diabetes. However, no risk calculators previously existed for OA. The OA Risk Calculator provides information about risk factors and the chance of developing OA if these factors are modified. For those already diagnosed with OA, the calculator gives information about the user’s risk of total joint replacement.

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Spotlight

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) features a recent publication on the cost-effectiveness of several pain medications among older adults with OA and co-existing diabetes and heart disease.

The study, published in Osteoarthritis and Cartilage, found that naproxen-based treatments were more cost-effective in this study population than either tramadol or celecoxib. Click here to learn more.

Losina Earns International Osteoarthritis Clinical Research Award

Elena Losina, PhD, co-director of the Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) in the Department of Orthopedic Surgery, and director of the Policy and Innovation Evaluation in Orthopaedic Treatments (PIVOT) Center has received the Osteoarthritis Research Society International (OARSI) Clinical Research Award for health policy and medical decision-making research in osteoarthritis. She received the award at the 2016 OARSI Congress in March in Amsterdam.

Losina is a founding director of BWH’s Policy Innovation eValuations in Orthopedic Treatments (PIVOT) Research Center and a principal investigator in the Methodology Core of the Robert Brigham Multidisciplinary Clinical Research Center at BWH. She also directs the Statistical Center for Biomarkers Consortium, an international collaboration to establish the prognostic value of biomarkers in osteoarthritis. She has published more than 300 peer-reviewed articles and leads a National Institutes of Health-funded multi-site project to conduct health policy evaluations related to surgical and non-surgical management of knee osteoarthritis.

OARSI is the leading osteoarthritis research organization in the world. The OARSI Clinical Research Award is given to one member each year in recognition of a body of clinical research of significant international impact

Policy and Innovation eValuation in Orthopedic Treatments (PIVOT) Center launched in BWH’s Department of Orthopedic Surgery

Affecting more than half of adults in the U.S., low back pain, osteoarthritis and musculoskeletal trauma are the three most common musculoskeletal conditions leading to emergency department and physician visits and hospital stays. Nearly $800 billion, or about 5 percent of the U.S. economy, goes towards diagnosing, treating, and managing musculoskeletal conditions.

“America spends more money on managing musculoskeletal conditions than it does on Social Security benefits for retired persons and their families,” said Elena Losina, PhD, professor of Orthopedic Surgery at BWH’s Department of Orthopedic Surgery and Harvard Medical School. “As people live longer and baby boomers age, this burden will increase.”

To help address these issues, BWH has launched the Policy and Innovation eValuation in Orthopedic Treatments (PIVOT) Center in the Department of Orthopedic Surgery. The research conducted by the PIVOT Center will help policy makers, physicians and patients to maximize treatment health benefits while reducing the overall economic burden of musculoskeletal diseases.

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