In 2006, the National Institute of Arthritis, Musculoskeletal, and Skin Diseases (NIAMS) awarded our group a grant to: develop a computer-simulation model of the natural history and management of knee OA and use the model to conduct policy evaluations on the value and design of specific knee OA treatment and monitoring strategies. Since then, we built and validated the OAPol Model and produced peer-reviewed publications and abstracts. Additional manuscripts are under review or in preparation.

Below you will find brief descriptions of several of our exciting ongoing projects.  To learn more about our past, published research projects, please refer to the Published Research page.

 

Weight Loss Regimens for OA Management
Recent evidence suggests that weight loss through diet and exercise may help to reduce pain and improve function in patients with osteoarthritis (OA).  In response to these new developments, we aim to incorporate weight loss into our model’s OA treatment regimens.  This will allow us to extend the results of current research and to estimate the large-scale benefits and cost-effectiveness of weight loss as a treatment for OA. We are also working on establishing the budget impact of funding weight-loss programs for knee osteoarthritis patients.

Antibiotic Prophylaxis following TKR in Diabetes and Rheumatoid Arthritis Patients
The administration of antibiotic prophylaxis (AP) before dental procedures following total knee replacement (TKR) remains inconclusive and controversial. Certain comorbidities, including diabetes mellitus and rheumatoid arthritis, are associated with increased odds of developing infections. In this analysis, we aim to evaluate the cost-effectiveness of administering AP to patient cohorts with elevated risks of infection. This research evaluates whether the reduction in prosthetic joint infections outweighs the impacts of adverse reactions to antibiotics.